A trial will compare outpatient and hospital initiation of ventilation for people with ALS
Original source
Outpatient versus inpatient initiation of home mechanical ventilation in patients with amyotrophic lateral sclerosis - a protocol for a randomised trial. (opens in a new tab)Compass summarised this from the study's abstract.
Study details
- Study type
- Trial protocol
- Studied in
- Human
- Trial registration
- NCT05829330
A randomised trial will compare starting non-invasive ventilation (NIV) at home with close telemonitoring against starting it during a one- to two-night hospital stay. The trial plans to enrol 46 people with amyotrophic lateral sclerosis (ALS) and will measure NIV use and treatment satisfaction after three months.
Why this matters
If outpatient initiation is shown to be no worse for NIV adherence, starting treatment at home could offer an alternative to hospital admission. This protocol reports a planned study, not results, so it does not currently change treatment or show that home initiation is safe or effective.
Limitations and context
This is a protocol for a planned, non-inferiority randomised trial, not a report of findings. The planned sample is small at 46 participants, and the study will assess outcomes over three months. Whether outpatient initiation works as well as hospital initiation remains to be established.