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ALS Untangled advises against antifungal drugs for ALS

Original source

Anti-fungalsALSUntangled · 26 February 2020

ALS Untangled says there is no established evidence that fungi occur in the brains of people with ALS or that antifungal drugs affect disease progression. The group advises people with ALS not to take antifungal drugs for ALS because the medicines can cause harm.

Why this matters

This applies to people considering antifungal drugs as an ALS treatment. The review found no preclinical ALS model studies, verified ALS cases, or clinical trials showing significant benefit, so these drugs should not be viewed as an evidence-based ALS treatment.

Limitations and context

This is an expert review, not a clinical trial or primary research study. It reports that the available evidence is absent or unknown, and recommends that independent laboratories investigate the question using more appropriate methods.

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