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ALS Untangled does not advise glutathione supplements for ALS

Original source

GlutathioneALSUntangled · 29 November 2019

ALS Untangled advises against using glutathione or cysteine-containing supplements as an ALS treatment. Its review says small clinical trials found no significant benefit, despite plausible mechanisms, positive preclinical findings and two case reports.

Why this matters

People with ALS and their families should not view these supplements as treatments supported by clinical evidence. The review describes them as appearing reasonably safe, but the reported lack of benefit means they should not be taken for ALS on this evidence alone.

Limitations and context

This is an independent expert review, not a new clinical trial. The evidence included small clinical trials, preclinical research and two case reports, so the findings are limited; the review does not establish whether every supplement or formulation has the same effects.

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