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ALS Untangled does not recommend antiretrovirals as an ALS treatment

Original source

AntiretroviralsALSUntangled · 25 April 2018

ALS Untangled says there is not enough evidence to recommend antiretroviral drugs for people with ALS who test negative for HIV and human T-cell lymphotropic virus. The group noted that two antiretroviral trials were ongoing in 2018.

Why this matters

This means antiretrovirals should not be considered an established ALS treatment based on this review. The review also says it remains unclear whether increased human endogenous retrovirus expression in some people with ALS is beneficial, neutral or harmful, or whether the drug targets are active in ALS.

Limitations and context

This is an independent expert review from 2018, not a report of trial results. The review did not establish whether antiretrovirals help or harm people with ALS; results from the cited trials would be needed to assess their use.

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