ALS Untangled does not recommend resveratrol as an ALS treatment
Original source
Resveratrol (opens in a new tab)ALS Untangled reviewed resveratrol, a dietary supplement, and found possible biological mechanisms and benefits in animal models of one type of familial ALS. No trials of resveratrol in people with ALS had been conducted at the time of the review. The review does not recommend using it as an ALS treatment because benefits are unknown and potential risks include gastrointestinal problems, weight loss and serious kidney toxicity.
Why this matters
This means resveratrol has not been shown to slow ALS or benefit people with ALS in clinical trials. Anyone considering it should be aware that the review found possible harms and does not support its use as an ALS treatment.
Limitations and context
This is an independent expert review, not a clinical trial. The reported benefits are from animal models, and the available safety findings came from trials in other populations. Well-designed clinical trials in people with ALS would be needed to assess whether resveratrol is effective and safe.