ALS Untangled reviewed curcumin as a possible ALS treatment
Original source
Curcumin (opens in a new tab)ALS Untangled reviewed the available evidence on oral curcumin for people with ALS (PALS). The review described theoretical mechanisms, flawed preclinical findings, improvements in three people receiving regimens that included curcumin, and a small pilot trial reporting some benefit. The reviewers said some of them planned a trial of Theracurmin, a curcumin formulation, at 90 mg twice daily.
Why this matters
Curcumin is being considered for further study, but this review does not establish that it treats ALS. The reported improvements have alternative possible explanations, and the preclinical and clinical evidence described is limited. A planned trial would be needed to test the treatment more rigorously.
Limitations and context
This is an expert review, not a new primary research study. The review describes flawed preclinical studies, three individual cases with possible alternative explanations, and one small pilot trial. It reports that a trial was planned, not that the trial had been completed or had produced results.