ALS Untangled says tamoxifen is not yet supported as an ALS treatment
Original source
Tamoxifen (opens in a new tab)An ALS Untangled review found that tamoxifen has plausible mechanisms and at least one positive preclinical study related to ALS. One case report and two small human trials suggested slower disease progression with higher doses, but the evidence is not sufficient to recommend tamoxifen for treatment.
Why this matters
This information may interest people with ALS and their clinicians, but it does not establish that tamoxifen works or should be used for ALS. A larger human clinical trial, including research on an 80-milligram daily dose, is needed.
Limitations and context
The evidence described consists of a case report, two small human trials and preclinical research. The source is an expert review, not a new clinical trial, and it reports associations rather than establishing that tamoxifen slows ALS progression. The review also mentions a study suggesting lower ALS risk, but says this finding needs independent replication.