ALS Untangled does not recommend ivermectin for ALS
Primary source of 2
ALSUntangled #84 - ivermectin. (opens in a new tab)Study details
- Studied in
- Human, Mouse
Population inferred from the title and abstract by Compass.
Related topics
ALS Untangled reviewed ivermectin as a possible ALS treatment and found limited evidence. One study in SOD1 mice reported modest neuroprotective effects, but this result has not been replicated. The review found no clinical trials and no apparent benefit in two people with ALS who had progression data while taking ivermectin.
Why this matters
Ivermectin is not supported as an ALS treatment by the evidence reviewed. Its long-term daily safety in people with ALS has not been established, and some formulations can cause serious side effects. The review therefore does not recommend using it for ALS at this time.
Limitations and context
This is an expert review, not a clinical trial. The evidence included one unreplicated mouse study and informal data from two people with ALS. No ALS clinical trials were identified, and long-term safety data were unavailable. The PubMed source provides only the review title and no article text.