Compass is still being developed and is effectively in beta. Some content and features may be incomplete, change, or not work as expected.
Content is anchored to trusted sources where available, but Compass has not yet been clinically reviewed. It provides general information rather than medical advice.
Feedback helps us identify gaps, errors, usability problems and opportunities to improve Compass over time.
Nuedexta official website
Part of Nuedexta
Open source (opens in a new tab)Link checked August 2026
About this source
Nuedexta’s official clinical information.
Where this source is used
Used in 3 places across 1 domain.
Questions
Medical Care
Treatments
- What is Nuedexta and how is it used in ALS/MND?
Supports this
“Nuedexta can affect heart rhythm, so a doctor may check heart rhythm before someone starts it, and heart disease or a family history of rhythm problems needs raising first.”
States that Nuedexta may cause serious side effects including changes in heart rhythm, that it may not be right for people with certain heart problems, and that a doctor may test heart rhythm before starting it.
If you have had heart disease or have a family history of heart rhythm problems. NUEDEXTA may cause serious side effects, including changes in heart rhythm.
IMPORTANT SAFETY INFORMATION: - What is Nuedexta and how is it used in ALS/MND?
Supports this
“Nuedexta cannot be combined with MAOIs or with quinidine and quinidine-related medicines, and MAOIs need a 14 day gap either side.”
The manufacturer's own safety information, which lists this first among the things to tell a doctor before starting Nuedexta and states the 14 day separation for MAOIs explicitly. The same section also covers allergic reactions to quinidine-like medicines, heart rhythm problems and signs of serotonin syndrome, which is why the answer routes people to their prescriber rather than listing it all.
If you are taking monoamine oxidase inhibitors (MAOIs), quinidine, or quinidine-related drugs. These can interact with NUEDEXTA causing serious side effects. MAOIs cannot be taken within 14 days before or after taking NUEDEXTA.
IMPORTANT SAFETY INFORMATION:
Resources
Medical Care
Treatments
- What is Nuedexta and how is it used in ALS/MND?
Further reading
Prescribing information and safety considerations
This is an external source. Compass links to it and describes it but does not hold rights over it. Opening it takes you to the publisher’s own site.