C9orf72-related protein buildup was linked to increased histone H3 phosphorylation
Original source
C9orf72 Dipeptide Repeat Proteinopathy Is Linked to Increased Histone H3 Phosphorylation on Serine 10. (opens in a new tab)Compass summarised this from the study's abstract.
Study details
- Studied in
- Human
Population inferred from the title and abstract by Compass.
Related topics
A study found that proline-arginine dipeptide repeats linked to C9orf72-associated ALS and frontotemporal dementia increased phosphorylation of histone H3 at serine 10. The finding was seen in a yeast model and in fibroblast and induced pluripotent stem cell lines from people with C9orf72-associated ALS. Reducing the yeast kinase responsible for this modification improved growth suppression in the model.
Why this matters
The results identify histone H3 phosphorylation at serine 10 as a possible mechanism or treatment target in C9orf72-related disease. However, the work was performed mainly in yeast and cultured cells, so it does not yet change treatment for people with ALS or frontotemporal dementia.
Limitations and context
This was primary laboratory research using a yeast overexpression model and patient-derived cultured cell lines, not a clinical trial or treatment study. The findings need confirmation in more disease-relevant models and in people before their clinical significance is known.