ResearchCase reportHuman
A VCP variant was linked to an unusual pattern of tau buildup in the nervous system
Provides detailed evidence about VCP variants, astrocytic tau aggregation and multisystem proteinopathy.
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ResearchReviewHumanAnimal
A review examines how astrocytes may contribute to ALS and other neurological diseases
Relevant to researchers studying astrocyte dysfunction, evolution, and cell-specific therapeutic targets in ALS.
ResearchHuman
Study finds racial and ethnic differences in ALS progression and survival among U.S. Veterans
Mainly of interest to researchers studying ALS trajectories, disparities and longitudinal modelling.
ResearchHumanMouse
A drug candidate that blocks BAX protected motor neurons in laboratory studies
Mainly of interest to researchers studying apoptosis and ALS motor-neuron models
Research
Engineered nanopores detect proteins linked to ALS and other diseases
Introduces programmable nanopores for single-molecule profiling of disease-associated proteins, including ALS-linked SOD1 peptides.
ResearchHuman
C9orf72 ALS study finds little difference in cognition or behaviour, except visuospatial skills
Mainly of interest to researchers studying genotype–phenotype relationships and cognitive outcomes
ResearchHuman
Urbanization and greenness were not linked to ALS risk in a Canadian study
Provides matched case-control evidence and exposure methods for studying urbanization and greenness.
ResearchHuman
ATXN2-related disease may sometimes follow a recessive inheritance pattern
Relevant to researchers studying repeat expansions, gene dosage and ALS mechanisms
ResearchHuman
A German registry study found that 12% of people with ALS lived at least 10 years after symptoms began
Mainly of interest to researchers studying ALS prognosis and epidemiology
ResearchHuman
Butyrate reduced ALS-linked protein clumps and improved movement in worms and cells
Directly informs HDAC inhibition, SOD1 aggregation and ALS model research
ResearchHumanMouse
Engineered delivery system clears harmful Tau and TDP-43 in disease models
Directly informs targeted autophagy and extracellular-vesicle strategies for TDP-43 pathology
ResearchReviewHumanAnimal
The nucleolus may link cellular stress to ALS and other neurodegenerative diseases
Mainly of interest to researchers studying nucleolar stress, C9orf72-linked ALS/FTD and neurodegeneration.
ResearchHuman
SIGMAR1 variants linked to a slowly progressing inherited motor neuropathy, not ALS
Mainly of interest to researchers studying SIGMAR1 genetics and motor-neuropathy classification
ResearchHumanMouse
Electroacupuncture improved movement and survival in an ALS mouse study
Provides mechanistic and outcome data on NLRP3 inflammasome modulation in an SOD1 ALS mouse model.
ResearchReviewHumanAnimal
A review outlines how immune responses might guide more precise ALS treatments
Detailed synthesis of neuroimmune mechanisms, biomarkers and trial-design priorities.
ResearchHuman
ALS linked to C9orf72 repeat expansion showed greater difficulty interpreting thoughts and emotions
Relevant to researchers studying genotype-linked cognitive and affective theory-of-mind impairment
ResearchHumanMouse
Changing ATXN2 splicing reduced ALS-related TDP-43 damage in cells and mice
Directly advances research on ATXN2 splicing, ASOs and TDP-43 pathology
Research
A review proposes grouping several neurodegenerative diseases by shared TDP-43 pathology
Directly relevant to researchers studying TDP-43 pathology, staging and mechanism-based biomarkers.
ResearchReviewHuman
Engineered microbes could deliver treatments in a more targeted way
Summarises engineering, delivery, safety and translational questions in living microbial therapeutics.
Research
Glial cell lipid changes affect age-related movement in flies
Directly informs glial sphingolipid biology, lipid-droplet readouts and age-related motor dysfunction.
Research
Are We Ready to Recognize TDP-43-Associated Neurodegenerative Disease?
Mainly of interest to researchers examining TDP-43 disease mechanisms and diagnostic concepts.
ResearchHumanAnimal
Computer study links non-nutritive sweeteners with pathways involved in neuroinflammation
Provides computational targets and pathways for investigating non-nutritive sweeteners in ALS and neuroinflammation.
ResearchSystematic reviewHuman
Occupational pesticide exposure linked to higher ALS risk
Directly relevant to researchers studying environmental epidemiology and ALS risk.
ResearchHuman
A FUS gene variant was linked to tremor and movement symptoms in a young adult with motor neuron disease
Mainly of interest to researchers studying FUS variants and phenotypic heterogeneity.
ResearchHuman
Researchers create two stem-cell lines from people with C9orf72-related ALS
Provides validated C9orf72 patient-derived iPSC lines for disease-mechanism studies.
Research Discussion
Informational study on ALS mimics
Relevant to clinicians evaluating possible ALS mimics and differential diagnoses.
ResearchHuman
A distinct astrocyte RNA pattern in Alzheimer’s disease runs in the opposite direction in ALS
Provides replicated donor-level lncRNA findings and methodological insights for ALS neurobiology research
ResearchHuman
Wearable brain monitoring detects altered prefrontal responses during cognitive testing in ALS
Mainly of interest to researchers studying neurovascular coupling, cognition, and fNIRS biomarkers in ALS.
Research
A new way of looking at ALS focuses on vulnerability across the entire motor unit
Mainly of interest to researchers studying motor-unit vulnerability and disease mechanisms
ResearchMouse
Study identifies two stages of TDP-43 pathology in Alzheimer’s disease mice
Relevant to researchers studying TDP-43 pathology, transcriptional states and therapeutic targets
Research Reporting
Frailty-based screening tool may help flag people at higher risk of ALS
Relevant to researchers studying ALS epidemiology, prediction and risk factors
ResearchHuman
PET network analysis detects brain connectivity changes in ALS
Provides a new Wasserstein-distance method and classification data for PET-based network research
ResearchMouse
TDP-43 was found to support muscle stem cell maintenance and repair
Important for researchers studying TDP-43, satellite-cell maintenance and skeletal-muscle regeneration.
ResearchHumanMouse
A study links higher neuronal TAF15 to oxidative stress in ALS and FTD
Important for researchers studying TAF15, oxidative stress, gliosis and potential antioxidant interventions.
ResearchSystematic reviewHuman
A review finds reduced corneal nerve measures in amyotrophic lateral sclerosis
Mainly of interest to researchers studying neurodegenerative biomarkers, CCM metrics and protocol standardisation.
ResearchReviewHuman
Mitochondrial energy-production problems may be a downstream feature of ALS and other neurodegenerative diseases
Mainly of interest to researchers studying Complex V, bioenergetics and neurodegeneration.
ResearchSystematic reviewHuman
Gold Coast criteria may help diagnose ALS earlier, but mimic conditions still need to be ruled out
Relevant to clinicians applying and interpreting ALS diagnostic criteria
ResearchHuman
Pre-disease pollutant biomarkers were linked to shorter ALS survival in a Danish cohort
Mainly of interest to researchers studying environmental determinants and ALS survival.
ResearchReviewHumanAnimal
Review examines how long non-coding RNAs may influence motor neuron diseases
Synthesises lncRNA ceRNA mechanisms, evidence gaps and research directions in motor neuron disease
ResearchReview
A review examines mitochondria-targeted nanotherapies for ALS and other neurodegenerative disorders
Relevant to researchers studying mitochondrial dysfunction, targeted delivery and translational barriers in ALS.
ResearchReviewHumanAnimal
A review proposes four phases for inflammation in ALS
Relevant to researchers studying neuroinflammation, immune-cell states and stage-dependent therapeutic targets.
ResearchReviewHumanAnimal
What PCSK9 inhibitors may mean for neurodegenerative diseases
Mainly of interest to researchers following PCSK9 biology, genetics and therapeutic mechanisms.
ResearchReviewHuman
Review outlines regenerative medicine strategies being explored for ALS and other neurodegenerative diseases
Relevant to researchers tracking stem-cell strategies, clinical advances and open questions in neurodegeneration
ResearchHuman
A blood test measures TDP-43 activity in ALS
Introduces a large-sample functional TDP-43 serum assay with genotype and longitudinal analyses
ResearchReview
A review links ALS neuron loss to interacting cell-death pathways
Relevant to researchers studying regulated cell death, neuroinflammation and translational therapeutic targets in ALS.
ResearchHuman
Nutritional vulnerability in ALS was linked to healthcare setting in a study from Portugal
Relevant to clinicians assessing nutrition within healthcare and referral contexts
Research Reporting
Heavy exercise tied to earlier disease onset in ALS patients
Mainly of interest to researchers studying environmental factors and disease onset
ResearchHuman
A machine-learning study identified drug-repurposing candidates for ALS
Provides machine-learning, transcriptomic, pathway, and drug-repurposing hypotheses for further validation.
ResearchReviewHuman
Circular RNAs may help explain how ALS develops
Provides a systematic review and computational analysis of circRNAs, RNA-binding proteins, and ALS mechanisms.
ResearchHuman
UNC13A cryptic splicing was linked to cognitive decline in Alzheimer’s disease
Relevant to researchers studying UNC13A cryptic splicing, TDP-43 pathology and neurodegeneration.
ResearchHuman
A large study found sensory testing abnormalities in most people with motor neuron disease
Important for researchers studying cortical hyperexcitability and multisystem MND mechanisms.
ResearchHuman
A Catalonia study linked some PM10 sources to toxic effects in human nerve cells
Relevant to researchers studying environmental neurotoxicity, oxidative stress and disease mechanisms.
ResearchReview
A review links sleep-wake disruption in ALS and other neurodegenerative diseases to altered brain activity
Mainly of interest to researchers studying shared sleep-wake mechanisms and neuronal hyperexcitability in neurodegeneration
Research Reporting
AI voice analysis may help doctors spot early signs of ALS, study suggests
Mainly of interest to researchers following AI-based voice biomarkers and diagnostic methods.
ResearchHumanMouse
Brain-penetrant TTBK1 inhibitors reduce TDP-43 pathology and improve cognition in a mouse model
Important for researchers studying selective TTBK1 inhibition, TDP-43 pathology and translational models.
ResearchHuman
An international study found that EQ-5D-5L scores worsened over time in ALS
Important for multinational ALS outcomes research and health-economic comparisons
ResearchHuman
U.S. motor neuron disease mortality rates declined from 2010 to 2023
Mainly of interest to researchers studying MND epidemiology and demographic variation.
ResearchHuman
Higher physical activity was associated with lower ALS risk in a UK Biobank study
Important for researchers studying ALS epidemiology, physical activity and genetic risk interactions.
ResearchReview
A review maps how mitophagy pathways may relate to neurodegeneration
Relevant to researchers studying mitophagy mechanisms and therapeutic opportunities in neurodegeneration.
Research
An analysis found that orthopaedic abstracts usually sound more certain than their discussions
Relevant to researchers studying scientific communication, reporting bias and AI use of abstracts.
Research
A correction was published for a study on BIM and motoneuron loss in an ALS model
Relevant to researchers tracking corrections to motoneuron-loss research involving BIM.
ResearchHuman
A historical review describes ALS as a multisystem disorder
Useful historical context for researchers studying ALS classification and multisystem disease features.
Research Reporting
NfL changes may help predict treatment benefit in ALS
Mainly of interest to researchers studying ALS biomarkers and therapeutic response
ResearchHuman
Long-term follow-up linked selenium supplementation to higher ALS incidence in SELECT
Mainly of interest to researchers studying environmental exposures and ALS epidemiology.
ResearchHuman
A light-activated compound sensed viscosity and reduced TDP-43 aggregation in laboratory models
Directly informs viscosity sensing, TDP-43 aggregation and controlled drug release methods
ResearchHuman
A review found no new ALS-causing variants in four unresolved genomic regions
Relevant to researchers studying ALS gene discovery, pedigrees and rare-variant methods.
ResearchHuman
Researchers identify a signaling pathway that controls ADH5/GSNOR in SOD1 ALS cell models
Defines a redox-dependent ATM-CHK2-SOD1 pathway and identifies ADH5/GSNOR as a potential target.
ResearchAnimal
A guinea pig pregnancy study found no measurable benefit from dimethyl fumarate
Provides a guinea-pig pregnancy model and maternal-fetal transcriptomic data for Nrf2 and DMF research.
ResearchHuman
A study identified four apathy profiles in depression and major neurocognitive disorder
Mainly of interest to researchers studying apathy phenotypes and neurodegenerative disease assessment.
ResearchHuman
A prospective clinic cohort is being used to guide personalised brain-computer interfaces
Mainly of interest to researchers studying clinical phenotypes and personalised brain-computer interface design
ResearchReviewHumanAnimal
A review examines cGAS-STING signaling as a possible target in ALS
Directly relevant to researchers studying cGAS-STING mechanisms and therapeutic development across neurodegenerative diseases.
ResearchHuman
Tofersen treatment did not lower blood SOD1 activity in a study of people with SOD1-related ALS
Mainly of interest to researchers studying SOD1 activity, mutation effects and tofersen mechanisms.
ResearchHuman
A Chinese study describes clinical and genetic differences in young-onset ALS
Mainly of interest to researchers studying age-dependent ALS genetics and trial design.
ResearchHuman
Voice disorders were linked to a higher risk of later cognitive decline in a large health-record study
Mainly of interest to researchers studying voice biomarkers, cognition and neurodegenerative disease.
ResearchHumanMouse
Review explores whether metformin could help treat ALS and other neurodegenerative diseases
Provides a mechanistic framework linking metabolic, mitochondrial and inflammatory pathways across neurodegenerative diseases.
ResearchReviewHumanAnimal
A review examines how neurons may contribute to inflammation in ALS
Relevant to researchers studying neuron-driven neuroinflammation and therapeutic targets in ALS.
ResearchHuman
A review describes emerging uses of SV2A PET imaging in ALS and other neurodegenerative diseases
Relevant to researchers studying synaptic pathology, SV2A PET methods, and ALS biomarker development.
ResearchReview
A review links physical activity with gut-brain pathways relevant to ALS
Mainly of interest to researchers studying myokines, microbiota and neuroinflammatory mechanisms in neurodegeneration.
ResearchHuman
A review links age-related LINE-1 activation with ALS biology
Relevant to researchers studying epigenetic aging, LINE-1 activity and ALS mechanisms.
ResearchReviewHuman
A review examines oxidative stress and inflammation across neurodegenerative diseases including ALS
Relevant to researchers tracking oxidative stress, mitochondrial dysfunction and antioxidant-delivery strategies in ALS.
Research Reporting
Workplace exposure to pesticides boosts risk of ALS, study finds
Important for researchers studying environmental epidemiology and ALS causation.
ResearchHuman
Neck weakness was linked to faster respiratory decline in a 324-person MND study
Relevant to clinicians using neck weakness as a marker for respiratory monitoring and prognosis.
ResearchHuman
A new analysis tool identified candidate ALS predisposition genes using external biobank data
Directly relevant to rare-variant methods, biobank controls, and candidate ALS predisposition genes
ResearchHuman
MRI study finds altered fluid movement around blood vessels in motor neuron disease
Provides imaging evidence linking glymphatic dysfunction with motor neuron disease phenotypes and white-matter damage
ResearchReviewHumanAnimal
A review links amino acid imbalance with processes involved in ALS
Mainly of interest to researchers studying excitotoxicity, oxidative stress and metabolic biomarkers.
ResearchCommentary
Reply to the comment on "Association of anti-glycolipid IgG with respiratory function decline in amyotrophic lateral sclerosis".
Relevant to researchers assessing interpretation and debate around a respiratory biomarker study
ResearchHumanMouse
Trehalose improved muscle function in a mouse model of HSPB8-related myopathy
Provides a knock-in model linking HSPB8, autophagy and TDP-43 pathology and tests trehalose preclinically.
ResearchMouse
Researchers generated mouse models carrying single-copy mutant human SOD1 genes
Directly relevant to researchers studying SOD1 models and genome-editing therapy evaluation.
ResearchHuman
A study identifies relative hip abductor preservation in ALS
Relevant to researchers studying selective muscle involvement and diagnostic biomarkers in ALS.
ResearchReview
A review proposes rebuilding the environment around nerve cells to support axon regeneration
Provides a framework and research directions for integrating intrinsic growth pathways with engineered environments
Research Reporting
Study finds traumatic brain injury may be sign, not cause, of ALS
Mainly of interest to researchers studying ALS causation and disease-associated injuries.
ResearchCase reportHumanUpdated
Muscle ultrasound may help diagnose motor neuron disease earlier and track respiratory decline
Relevant to clinicians evaluating ultrasound alongside EMG in suspected MND
ResearchHuman
An isolated nucleolus assay links electrostatic forces to changes caused by disease-associated proteins
Important for researchers studying nucleolar integrity, arginine-rich dipeptide repeats and C9orf72-linked neurodegeneration.
ResearchCommentary
A reported anti-IgLON5 disease case resembled motor neuron disease after decades of sleep symptoms
Relevant to clinicians evaluating potentially reversible mimics of motor neuron disease.
ResearchReview
A review highlights IL-6 trans-signalling as a possible target in ALS
Mainly of interest to researchers studying IL-6 signalling, neuroinflammation and therapeutic targets.
ResearchHuman
An AI method mapped TDP-43 and tau inclusions in brain tissue from Alzheimer’s-related conditions
Provides an AI-based 3D segmentation method and regional data on TDP-43–tau inclusion maturation.
ResearchHuman
A study questions whether right- and left-sided temporal FTD are separate disorders
Mainly of interest to researchers studying FTD classification, neuroimaging and clinical phenotypes.
ResearchCommentary
Comment on "Association of anti-glycolipid IgG with respiratory function decline in amyotrophic lateral sclerosis"
Mainly of interest to researchers assessing anti-glycolipid antibodies and ALS respiratory outcomes.
Research Reporting
Blood test may improve accuracy and reduce false ALS diagnoses
Relevant to clinicians evaluating diagnostic accuracy and potential blood-test use
ResearchHumanMouse
An anti-TDP-43 intrabody changed disease-related pathways but did not improve symptoms in ALS mice
Directly informs TDP-43 mechanisms, neuroinflammation, metabolism and biomarker target engagement
ResearchHumanMouse
Neural stem cell vesicles slowed disease progression in an ALS mouse model
Directly informs extracellular-vesicle therapy, motor-neuron protection and p53-pathway research.
ResearchHuman
Patient-derived microglia models show differences between genetic and sporadic FTD
Directly informs microglial phagocytosis, autophagy, lysosomal pathways, and C9orf72 versus sporadic disease models.
ResearchHuman
An antibody improved detection of TDP-43 pathology in ALS and related disorders
Directly informs TDP-43 immunohistochemistry, pathology subtyping and translational biomarker development
ResearchReviewMouse
A review examines how SQSTM1 modifications regulate autophagy
Synthesizes how SQSTM1 post-translational modifications regulate autophagy and neurodegeneration.
ResearchCommentary
A Neurology letter discusses possible biomarkers of upper motor neuron degeneration in ALS
Relevant to researchers studying cortical excitability and imaging biomarkers in ALS
Research Reporting
‘Unprecedented’ survival boost seen with new gene therapy in ALS model
Important to researchers studying gene therapy and survival outcomes in ALS models.
ResearchHuman
A Brazilian study found pathogenic gene variants in 30 people with motor neuron disease
Mainly of interest to researchers studying MND genetics, testing patterns, and population variation.
Research
Researchers mapped how four nanobodies bind to the ALS-related target EphA4
Provides high-resolution structural and biophysical insight into nanobody binding mechanisms for EphA4.
ResearchHuman
A new statistical method was illustrated using data from an amyotrophic lateral sclerosis trial
Directly relevant to researchers developing covariate-adjusted statistical methods for ALS randomized trials.
ResearchHumanAnimal
A fruit-fly study links C9orf72 repeat products in glial cells to reduced lifespan
Important for researchers studying glial toxicity, DPRs, ERV activation and C9orf72 disease models
ResearchHuman
Study finds different gut bacteria profiles in ALS patients with and without feeding tubes
Mainly of interest to researchers studying ALS microbiome composition, nutrition and potential microbiome-targeted interventions.
ResearchAnimal
Blocking GABA production caused motor deficits and motor neuron loss in rats
Offers experimental evidence linking spinal GABA synthesis inhibition to motor-neuron degeneration.
ResearchHumanMouse
Wild-type C9orf72 was linked to protein-clearance problems in experimental Huntington’s disease models
Relevant to researchers studying C9orf72, proteostasis and neurodegenerative disease mechanisms.
ResearchHuman
ALS language and executive problems show different brain-cell patterns
Mainly of interest to researchers studying cellular mechanisms of ALS cognitive phenotypes
ResearchCase reportHuman
Four people with SOD1 D91A ALS first developed progressive ataxia
Mainly of interest to researchers studying SOD1 genotype–phenotype relationships and diagnostic latency.
ResearchHumanCells
RNA exosome activity suppresses toxic protein production linked to C9orf72 ALS
Provides mechanistic evidence linking RNA-exosome surveillance and EXOSC3 to RAN translation and DPR production.
ResearchHuman
Export-biased TDP-43 disrupted nuclear function in cell models
Directly advances mechanistic understanding of TDP-43 autoregulation and insoluble accumulation
ResearchHuman
A small study used tongue ultrasound to measure atrophy in ALS
Mainly of interest to researchers studying quantitative bulbar biomarkers and ultrasound methods.
ResearchReview
A review examines how stress granules may contribute to ALS protein aggregates
Directly reviews stress granules, TDP-43 aggregation, USP10 and therapeutic research directions.
Research
A case report describes myofibrillar myopathy with pyramidal signs that mimicked ALS
Relevant to clinicians distinguishing myofibrillar myopathy from ALS.
ResearchAnimal
Paternal lead exposure caused multigenerational oxidative changes in fruit flies
Provides transgenerational oxidative-stress and antioxidant-gene findings for researchers studying toxicology and disease mechanisms.
ResearchHumanMouse
Researchers identify septin autoantibodies in three people with motor-predominant ALS-like disease
Mainly of interest to researchers studying septin autoimmunity, diagnostic biomarkers and disease mechanisms.
ResearchHuman
People newly diagnosed with ALS had higher nano- and microplastic levels than controls
Mainly of interest to researchers studying environmental exposures, neurotoxicity and ALS aetiology.
ResearchHuman
A CSF protein study identified genetic signatures linked to frontotemporal lobar degeneration
Directly informs proteomic signatures, genetic subgroup biology and diagnostic panel development.
ResearchHuman
A study links broader sensory-cortex excitability with shorter survival in sporadic ALS
Relevant to researchers studying cortical hyperexcitability and ALS pathophysiology.
ResearchReviewHuman
An umbrella review finds distinct iron-related MRI changes in ALS
Provides an umbrella synthesis of QSM methods, iron patterns, and evidence limitations across neurodegenerative diseases.
ResearchReviewHumanAnimal
A review examines how intron retention may influence ALS biology
Provides a focused review of intron retention, RNA biology, RBPs and therapeutic research directions in ALS.
ResearchHuman
A genetic study assessed sex-specific immune links in ALS and other neurodegenerative diseases
Directly informs sex-stratified genetic and immune-mechanism research
ResearchReviewHuman
A review describes how patient-derived stem cells helped identify ropinirole as an ALS drug candidate
Relevant to researchers studying stem cells, iPSC models, regenerative medicine and ALS drug discovery.
ResearchHuman
Tau changes in astrocytes were linked to neurodegeneration in younger donated brains
Relevant to researchers studying astrocytes, tau aggregation and selective vulnerability across neurodegenerative conditions.
ResearchReview
A review proposes a framework for studying monocyte-derived myeloid states in ALS and other neurodegenerative diseases
Provides a lineage-calibrated framework for interpreting monocyte states, disease models, and therapeutic targets.
ResearchHuman
A nationwide study has described motor neuron disease in Latvia from 2020 to 2024
Mainly of interest to researchers studying MND epidemiology, under-recognition and registries
ResearchHumanMouse
ALS altered lipid signalling in fast-twitch muscles before neurological symptoms in female mice
Provides muscle-specific lipid mediator data, human transcriptomic comparison and a negative therapeutic test
ResearchSystematic reviewHumanAnimal
A review finds genetic therapies improved several ALS measures in rodent studies
Provides a systematic synthesis of animal-model genetic therapy efficacy and bias.
ResearchHuman
A study identified cognitive and behavioral subtypes in non-demented ALS
Mainly of interest to researchers developing ALS neuropsychological phenotypes
ResearchHuman
Cerebrospinal fluid TMEM106B levels were linked to disease severity in frontotemporal dementia
Directly informs CSF biomarker, genotype, progression, and FTLD mechanism research
ResearchHuman
A study maps the order of biomarker and clinical changes across frontotemporal degeneration syndromes
Provides longitudinal biomarker timing and a framework for staging FTLD-associated syndromes.
ResearchHuman
Cognitive and behavioral changes were found early in people with primary lateral sclerosis
Mainly of interest to researchers studying extramotor involvement and PLS cognitive profiles
ResearchReviewHumanAnimal
A review outlines approaches to targeting TDP-43 in sporadic ALS
Mainly of interest to researchers studying TDP-43 pathology, cryptic exons, biomarkers and trial methodology.
ResearchHuman
A study links changes in PML nuclear bodies with TDP-43 aggregation in sporadic ALS
Directly informs research on PML nuclear bodies and TDP-43 inclusion formation
ResearchReviewHumanAnimal
A review highlights mitochondrial dysfunction in microglia as a potential ALS treatment target
Provides a cross-disease synthesis of microglial mitochondrial mechanisms and research targets.
ResearchHuman
A forensic autopsy study found overlapping abnormal proteins in young people exposed to urban air pollution
Relevant to researchers studying TDP-43, protein pathology, autopsy methods and environmental exposure.
ResearchHuman
Laboratory study links HIV and SARS-CoV-2 co-infection in brain cells to ALS-associated pathways
Mainly of interest to researchers studying proteomic, viral, glial and neuroinflammatory mechanisms linked to ALS.
ResearchHuman
A study mapped TDP-43 fragments in Alzheimer’s disease and age-related tauopathy
Relevant to researchers studying TDP-43 fragment biology and AI-based neuropathological quantification.
ResearchHuman
Locus coeruleus TDP-43 pathology was found in one-fifth of an autopsy cohort
Provides cohort evidence on locus coeruleus TDP-43 pathology, aging and clinical correlates.
ResearchHuman
Study links some hormone replacement therapy use with lower odds of LATE-NC
Mainly of interest to researchers studying TDP-43 pathology, aging and hormone effects.
ResearchHumanMouse
A review examines how ataxin-1 changes may contribute to neurological disease
Reviews ATXN1 gain- and loss-of-function evidence and its association with ALS and other neurological diseases
Research Reporting
ALS-causing gene mutations disrupt key protein machinery: Study
Directly concerns how ALS-associated mutations disrupt cellular protein machinery
ResearchReviewHuman
Brazilian experts recommend early genetic testing for people with ALS
Relevant to clinicians updating ALS genetic-testing practice and counselling
ResearchHuman
A Lithuanian study found pathogenic genetic variants in 15.7% of patients with motor neuron disease
Mainly of interest to researchers studying MND genetics and regional variation
ResearchHuman
Submaximal stimulation revealed different excitability patterns in healthy hand muscles
Directly informs motoneuron excitability methods and hypotheses about muscle-specific recruitment in ALS.
Research
A review examines how myelin and oligodendrocyte dysfunction may contribute to ALS
Relevant to researchers studying oligodendrocyte dysfunction and myelination pathways in ALS
ResearchObservational studyHuman
A remote digital assessment study found some measures could distinguish ALS from controls
Mainly of interest to researchers developing and validating ALS digital biomarkers
ResearchHuman
A study links premorbid traits and social exposures with behavioral impairment in ALS
Mainly of interest to researchers studying behavioral phenotypes, reserve, and risk stratification.
ResearchHuman
Free-water MRI detected additional white matter changes in people with ALS
Provides free-water-corrected diffusion MRI findings, clinical correlations and a preliminary diagnostic model.
ResearchHuman
A small study found no difference in chromosomal instability markers in oral cells from people with ALS
Provides negative case-control evidence about chromosomal-instability markers in ALS.
Research Reporting
Study finds 4-month diagnostic gap between key ALS types
Relevant to clinicians evaluating diagnostic delays and subtype-specific assessment.
ResearchSystematic reviewHuman
A systematic review finds suicidality is a concern in ALS, especially early after diagnosis
Relevant to assessing suicidality and psychosocial risk factors in early ALS care.
ResearchHuman
ALS rates varied by military branch and rank among U.S. veterans
Mainly of interest to researchers studying ALS epidemiology and occupational exposures.
ResearchReviewHumanAnimal
A review examines links between tau, RNA and stress granules in neurodegenerative disease
Summarises tau, RNA, and stress-granule mechanisms that open questions for neurodegeneration research.
ResearchReview
A review examines DNMT1 links to environmental signals and ALS vulnerability
Provides a broad framework linking DNMT1, environmental exposures, sex hormones, and ALS mechanisms.
ResearchCommentary
Amyotrophic Lateral Sclerosis in the Military: A Uniform Risk?
Mainly of interest to researchers studying ALS epidemiology and military exposures
ResearchHuman
Whole-genome sequencing found a likely genetic cause in 13% of people with ALS in a 500-person study
Mainly of interest to researchers studying ALS genetics and diagnostic yield
ResearchHuman
A study finds distinct molecular changes in brain and spinal cord regions in ALS
Offers spatial multi-omics data on distinct cortical and spinal molecular signatures and glial interactions.
ResearchHuman
A study linked cortical excitability patterns with brain chemistry changes in ALS
Provides mechanistic and longitudinal biomarker data linking cortical excitability with MRS profiles
Research
Phosphorylation redirected a TDP-43 segment into small particles in laboratory experiments
Provides mechanistic and structural evidence on phosphorylation-controlled TDP-43 assembly
ResearchHuman
Cognitive reserve was linked to different patterns of cognitive change in ALS
Mainly of interest to researchers studying cognitive reserve, disease progression and ALS cognitive phenotypes.
ResearchHumanMouse
An exploratory analysis found different cellular pathway signals in depression and ALS
Relevant to researchers studying shared ALS–depression mechanisms, transcriptomics, autophagy, and NAD+-linked pathways.
ResearchHuman
A 19-protein blood panel predicted future clinical ALS in some mutation carriers
Directly informs longitudinal proteomics, phenoconversion prediction and prevention-trial design.
ResearchHuman
Multi-omic study identifies synaptic changes linked to C9ORF72-related disease
Important for researchers studying synaptic dysfunction, cryptic transcripts, and C9ORF72 mechanisms.
ResearchHuman
YEATS-domain inhibition improved ALS-related outcomes in flies and protected stressed human neurons
Important for researchers studying stress signaling, ENL/AF9, and disease-context-dependent ALS mechanisms.
ResearchHuman
Methionine oxidation disrupts TDP-43 assembly through two mechanisms
Provides molecular and structural evidence on how methionine oxidation alters TDP-43 phase separation.
ResearchMouse
Intracerebroventricular SynCav1 gene delivery improved motor measures in ALS mice
Directly informs researchers studying AAV biodistribution, caveolin-1 biology and ALS motor-neuron models.
ResearchReview
A review examines auditory measures as possible biomarkers in ALS and other neurodegenerative diseases
Mainly of interest to researchers studying auditory biomarkers and neurodegenerative disease mechanisms.
ResearchHuman
A study developed an MRI-based AI model for predicting several dementia-related brain pathologies
Mainly of interest to researchers studying multimodal biomarkers, neuropathology prediction, and explainable AI.
ResearchReviewHumanAnimal
A review links R-loop regulation to several neurological diseases including ALS
Mainly of interest to researchers studying R-loops, TDP-43/FUS, SETX and neurodegeneration
ResearchHuman
A population study found tau-related astrocyte changes in most people aged 85 and older
Provides population-based data on ARTAG prevalence, anatomical patterns and associations with TDP-43 and vascular pathology.
ResearchReview
A review proposes targeting specific HSP90 proteins in ALS and other diseases
Mainly of interest to researchers studying proteostasis, chaperones and ALS mechanisms.
ResearchReview
A review proposes that ALS emerges when neural resilience and reserve can no longer compensate for accumulated stress
Relevant to researchers studying proteostasis, mitochondrial function, neuroimmune regulation and disease thresholds.
ResearchHuman
Cylindrospermopsin damaged human cell-based neural models in a laboratory study
Relevant to researchers studying neurotoxicity, stem-cell models and nervous-system biomarkers
ResearchHuman
Reduced heart-rate variability was linked to faster progression and shorter survival in ALS
Mainly of interest to researchers studying ALS progression, survival and cardiac biomarkers.
ResearchSystematic reviewHuman
A genetic analysis identifies proteins linked to frontotemporal dementia subtypes including cases overlapping motor neur
Relevant to researchers studying causal plasma proteins, proteomics and neurodegenerative disease mechanisms.
ResearchAnimal
A canine ALS-like disease study links sensory pathway damage with walking problems
Important for researchers studying SOD1 pathology, sensory pathways and disease-modifying factors in a canine model.
ResearchHuman
A case report links focal epilepsy with FUS-associated ALS
Mainly of interest to researchers studying FUS-ALS phenotypes and genotype-phenotype links.
ResearchReviewHumanAnimal
A review examines ADAR RNA editing in ALS and other brain disorders
Directly relevant to researchers studying ADAR dysregulation, RNA editing mechanisms, and therapeutic delivery
ResearchReviewHumanAnimal
A review finds gut microbiota links to ALS remain uncertain
Relevant to researchers studying microbiota-gut-brain mechanisms, disease signatures and translational research gaps.
ResearchHumanAnimal
A fruit-fly study links glial Fos activity to inflammation and motor decline in an ALS model
Provides a CRISPR Drosophila model linking glial Fos/Kayak regulation to age-dependent neuroinflammation and motor decline.
ResearchHuman
A meta-analysis found thinner retinal nerve fibre layers in people with ALS
Relevant to researchers studying retinal neurodegeneration and biomarker validation in ALS.
ResearchMouse
Site-targeted C3 inhibition reduced neurodegeneration in an ALS mouse model
Directly informs complement mechanisms, therapeutic targeting and ALS translational research
ResearchHuman
Troponin T and neurofilament light chain captured different aspects of ALS progression
Mainly of interest to researchers studying complementary ALS biomarkers and disease modelling.
ResearchHuman
A preprint reports shared lipid changes in frontotemporal degeneration and Alzheimer’s disease
Provides integrated lipidomic and proteomic evidence about shared lysosomal and lipid-homeostasis pathways across FTLD and Alzheimer’s disease.
ResearchHuman
Long-read sequencing links three CAA interruptions in ATXN2 repeats with ALS
Mainly of interest to researchers studying ATXN2 haplotypes, repeat interruptions and ALS genetics.
ResearchHuman
Sex-related differences were found in inflammatory markers and muscle ultrasound measures in an ALS study
Relevant to researchers studying sex-associated biomarkers, ultrasound measures, and ALS progression.
ResearchHumanMouse
Neuronal translation features may favor production of toxic C9orf72 repeat proteins
Important for researchers studying RAN translation and neuron-specific translational regulation
ResearchObservational studyHuman
A jaw muscle may offer an additional target for bulbar EMG in ALS
Relevant to clinicians performing bulbar electromyography and evaluating diagnostic options.
ResearchSystematic reviewHuman
A review finds blood neurofilament light chain may help measure treatment effects in ALS trials
Relevant to researchers studying NfL validation and disease- or intervention-specific biomarker interpretation
Research
Motor neuron disease disability rates increased in the Americas from 1990 to 2023
Mainly of interest to researchers studying MND epidemiology, burden trends and risk factors.
ResearchHuman
ALS patient-derived neuron networks showed dysfunction and increased centralisation
Directly informs ALS network mechanisms, human cellular modelling, electrophysiology, and compensation hypotheses.
ResearchHumanAnimal
A zebrafish ALS model identified tribenzylamine as a candidate compound
Offers a FUS zebrafish screening platform and mechanistic evidence for tribenzylamine.
ResearchSystematic reviewHuman
A review finds extracellular vesicle biomarkers for ALS promising but not ready for clinical use
Important for researchers evaluating extracellular-vesicle biomarker performance, heterogeneity, and replication needs.
From Curalysis
- Clinical trials need to leave the clinic2 months ago
- There’s No Map for This5 months ago
- On the Inside of a Clinical Trial7 months ago
Summarised by Compass using AI from the source material. These are not medical advice. Always read the original source.