Researchers generated stem cell lines from blood samples of two people with C9ORF72-associated ALS
Original source
Generation of Human-Induced Pluripotent Stem Cells from Peripheral Blood Mononuclear Cells of C9ORF72-Associated Amyotrophic Lateral Sclerosis Patients. (opens in a new tab)Compass summarised this from the study's abstract.
Study details
- Studied in
- Human, Cells
Related topics
Researchers described a method for reprogramming blood cells from two people with amyotrophic lateral sclerosis (ALS) linked to C9ORF72 repeat expansions into human induced pluripotent stem cells (hiPSCs). The cells showed markers of pluripotency and could be differentiated into cells representing all three germ layers. [S1]
Why this matters
These patient-specific cells could help researchers study the molecular basis of C9ORF72-associated ALS and create disease models. This laboratory work does not change treatment for people with ALS. [S1]
Limitations and context
The report describes a protocol based on samples from only two people. It establishes a laboratory cell model, not a treatment or evidence of benefit in patients. The cells' usefulness for understanding ALS still needs to be demonstrated in further research. [S1]