TMEM106B filament formation was linked more strongly to age than to TDP-43 or tau pathology
Original source
Associations between TMEM106B C-terminal fragment aggregation, age, and TDP-43 or tau pathology. (opens in a new tab)Compass summarised this from the study's abstract.
Study details
- Studied in
- Human, Cells
Related topics
A postmortem human-brain study found that fibrils made from TMEM106B C-terminal fragments commonly appeared after age 52. They were found across several brain regions and mainly in astrocytes and oligodendrocytes. The study found only a weak association with TDP-43 or tau pathology.
Why this matters
The findings add information about how TMEM106B relates to brain ageing and neurodegenerative pathology. They do not identify a treatment effect or change treatment for people with amyotrophic lateral sclerosis or other diseases. The study suggests that the role of TMEM106B fibrils in neurodegeneration remains unclear.
Limitations and context
This was a postmortem, observational study of human brain tissue, not a treatment study. It examined people aged 6 to 94 with several neurological conditions and healthy comparison subjects, but the source does not provide the sample size. The findings show associations and cannot establish that TMEM106B fibrils cause neurodegeneration or influence disease progression.