ResearchCase reportHuman
A VCP variant was linked to an unusual pattern of tau buildup in the nervous system
Provides detailed evidence about VCP variants, astrocytic tau aggregation and multisystem proteinopathy.
Compass is still being developed and is effectively in beta. Some content and features may be incomplete, change, or not work as expected.
Content is anchored to trusted sources where available, but Compass has not yet been clinically reviewed. It provides general information rather than medical advice.
Feedback helps us identify gaps, errors, usability problems and opportunities to improve Compass over time.
ResearchHumanMouse
Engineered delivery system clears harmful Tau and TDP-43 in disease models
Directly informs targeted autophagy and extracellular-vesicle strategies for TDP-43 pathology
ResearchHumanMouse
Changing ATXN2 splicing reduced ALS-related TDP-43 damage in cells and mice
Directly advances research on ATXN2 splicing, ASOs and TDP-43 pathology
Research
A review proposes grouping several neurodegenerative diseases by shared TDP-43 pathology
Directly relevant to researchers studying TDP-43 pathology, staging and mechanism-based biomarkers.
Research
Are We Ready to Recognize TDP-43-Associated Neurodegenerative Disease?
Mainly of interest to researchers examining TDP-43 disease mechanisms and diagnostic concepts.
ResearchMouse
Study identifies two stages of TDP-43 pathology in Alzheimer’s disease mice
Relevant to researchers studying TDP-43 pathology, transcriptional states and therapeutic targets
ResearchMouse
TDP-43 was found to support muscle stem cell maintenance and repair
Important for researchers studying TDP-43, satellite-cell maintenance and skeletal-muscle regeneration.
ResearchHuman
A blood test measures TDP-43 activity in ALS
Introduces a large-sample functional TDP-43 serum assay with genotype and longitudinal analyses
ResearchHuman
UNC13A cryptic splicing was linked to cognitive decline in Alzheimer’s disease
Relevant to researchers studying UNC13A cryptic splicing, TDP-43 pathology and neurodegeneration.
ResearchHumanMouse
Brain-penetrant TTBK1 inhibitors reduce TDP-43 pathology and improve cognition in a mouse model
Important for researchers studying selective TTBK1 inhibition, TDP-43 pathology and translational models.
ResearchHuman
A light-activated compound sensed viscosity and reduced TDP-43 aggregation in laboratory models
Directly informs viscosity sensing, TDP-43 aggregation and controlled drug release methods
ResearchHuman
A study linked TDP-43 to lung cancer growth through ferroptosis resistance
Provides mechanistic data on TDP-43, PCBP1/2 and ferroptosis in lung adenocarcinoma
ResearchHumanMouse
Trehalose improved muscle function in a mouse model of HSPB8-related myopathy
Provides a knock-in model linking HSPB8, autophagy and TDP-43 pathology and tests trehalose preclinically.
ResearchHuman
An AI method mapped TDP-43 and tau inclusions in brain tissue from Alzheimer’s-related conditions
Provides an AI-based 3D segmentation method and regional data on TDP-43–tau inclusion maturation.
ResearchHumanMouse
An anti-TDP-43 intrabody changed disease-related pathways but did not improve symptoms in ALS mice
Directly informs TDP-43 mechanisms, neuroinflammation, metabolism and biomarker target engagement
ResearchHuman
An antibody improved detection of TDP-43 pathology in ALS and related disorders
Directly informs TDP-43 immunohistochemistry, pathology subtyping and translational biomarker development
ResearchReviewHumanAnimal
The supplied review concerns Alzheimer’s disease rather than ALS or MND
Relevant to researchers studying TDP-43, mitochondrial dysfunction and neurodegenerative disease mechanisms.
ResearchHuman
Export-biased TDP-43 disrupted nuclear function in cell models
Directly advances mechanistic understanding of TDP-43 autoregulation and insoluble accumulation
ResearchReview
A review examines how stress granules may contribute to ALS protein aggregates
Directly reviews stress granules, TDP-43 aggregation, USP10 and therapeutic research directions.
ResearchReviewHumanAnimal
A review outlines approaches to targeting TDP-43 in sporadic ALS
Mainly of interest to researchers studying TDP-43 pathology, cryptic exons, biomarkers and trial methodology.
ResearchHuman
A study links changes in PML nuclear bodies with TDP-43 aggregation in sporadic ALS
Directly informs research on PML nuclear bodies and TDP-43 inclusion formation
ResearchHuman
A forensic autopsy study found overlapping abnormal proteins in young people exposed to urban air pollution
Relevant to researchers studying TDP-43, protein pathology, autopsy methods and environmental exposure.
ResearchHuman
A study mapped TDP-43 fragments in Alzheimer’s disease and age-related tauopathy
Relevant to researchers studying TDP-43 fragment biology and AI-based neuropathological quantification.
ResearchHuman
Locus coeruleus TDP-43 pathology was found in one-fifth of an autopsy cohort
Provides cohort evidence on locus coeruleus TDP-43 pathology, aging and clinical correlates.
ResearchHuman
Study links some hormone replacement therapy use with lower odds of LATE-NC
Mainly of interest to researchers studying TDP-43 pathology, aging and hormone effects.
Trials & TreatmentsReviewUpdated
Review highlights evidence and trial-design gaps for CTx1000, a TDP-43-targeting ALS therapy
Relevant to researchers studying TDP-43 degradation, target engagement and ALS trial methodology.
Trials & TreatmentsHumanMouse
An antibody fragment reduced ALS-related damage in cells and mice
Directly informs PC-OxPL mechanisms, TDP-43 pathology and AAV-scFv therapeutic development.
ResearchReviewHumanAnimal
A review examines links between tau, RNA and stress granules in neurodegenerative disease
Summarises tau, RNA, and stress-granule mechanisms that open questions for neurodegeneration research.
Research
Phosphorylation redirected a TDP-43 segment into small particles in laboratory experiments
Provides mechanistic and structural evidence on phosphorylation-controlled TDP-43 assembly
ResearchHuman
A meta-analysis links LATE-NC to dementia and several brain pathologies
Relevant to researchers studying TDP-43 pathology, genetics, and neurodegenerative disease mechanisms.
ResearchHuman
Methionine oxidation disrupts TDP-43 assembly through two mechanisms
Provides molecular and structural evidence on how methionine oxidation alters TDP-43 phase separation.
ResearchReviewHumanAnimal
A review links R-loop regulation to several neurological diseases including ALS
Mainly of interest to researchers studying R-loops, TDP-43/FUS, SETX and neurodegeneration
ResearchHuman
A population study found tau-related astrocyte changes in most people aged 85 and older
Provides population-based data on ARTAG prevalence, anatomical patterns and associations with TDP-43 and vascular pathology.
Trials & TreatmentsHumanMouse
Platelet factor 4 improved disease measures in SOD1 ALS mice
Mainly of interest to researchers studying PF4, OPTN-dependent autophagy and SOD1 pathology
ResearchHumanMouse
A perspective calls for broader ALS models beyond protein-focused mouse studies
Relevant to researchers studying protein pathology, transgenic models, and translational ALS methods.
ResearchReview
A review proposes how proteases may drive TDP-43 pathology
Relevant to researchers studying TDP-43 proteolysis, post-translational modification and drug discovery.
ResearchCase reportHuman
A case report describes coexisting PRNP and GRN variants in Gerstmann-Sträussler-Scheinker syndrome
Important case evidence about PRNP-GRN co-variation, TMEM106B, phenotype and neuropathology
ResearchMouse
Loss of microglial TDP-43 caused myelin abnormalities and motor deficits in mice
Provides mechanistic evidence linking microglial TDP-43, myelin handling and TREM2-DAP12 signaling.
ResearchReviewHumanAnimal
A review examines how phase separation may contribute to ALS-related protein aggregation
Provides a broad review of phase separation, protein aggregation and candidate therapeutic strategies involving TDP-43 and FUS.
ResearchHumanMouse
A small molecule protected neurons and extended survival in TDP-43 ALS models
Directly relevant to researchers studying TDP-43, mitochondrial dysfunction and ALS drug discovery.
ResearchHumanMouse
Researchers developed a PET tracer that targets abnormal TDP-43 in animal models
Highly relevant to researchers studying TDP-43 pathology, PET tracers and therapeutic development
ResearchReview
A review outlines ALS mechanisms, biomarkers and possible treatment targets
Relevant to researchers comparing ALS mechanisms, biomarkers and treatment targets across neurodegenerative diseases
ResearchHuman
ADAR2 RNA editing promoted TDP-43 export from the nucleus in cell and fly experiments
Important for researchers studying RNA editing, TDP-43 trafficking and ALS mechanisms
ResearchHumanAnimal
Study identifies protein features that drive shortened TDP-43 aggregation in neurons
Directly informs research on TDP-43 isoform aggregation, mislocalization and RNA-based mitigation.
ResearchHuman
A liver cancer study links higher TARDBP expression with poorer outcomes and weaker immune responses
Offers context on TARDBP/TDP-43 function and immune biology outside MND.
ResearchHumanMouse
Organoid study links TGF-β signaling to astroglial activation in progranulin-related frontotemporal degeneration
Directly informs astrocyte biology, TGF-β signaling, organoid models, and TDP-43 proteinopathy in GRN-related disease.
ResearchHumanMouse
TDP-43 disrupted sensory-cortex nerve projections in mice
Directly informs research on TDP-43, cortical axons, sensory involvement and developmental versus maintenance effects.
ResearchReviewHumanAnimal
A proposed Parkinson’s therapy targets extracellular alpha-synuclein
Relevant to researchers exploring lysosomal delivery and potential adaptation of protein-degradation methods to TDP-43.
Trials & TreatmentsMouse
Triumeq briefly improved motor function in a TDP-43 ALS mouse model
Relevant to researchers studying TDP-43 pathology, endogenous retroviruses and repurposed antiretroviral mechanisms.
Research Reporting
Imaging agent spots TDP-43 clumps in ALS patients in trial
Mainly of interest to researchers studying TDP-43 pathology and ALS biomarkers
Research
TDP-43 was found to help maintain and repair skeletal muscle satellite cells
Important for researchers studying TDP-43, satellite-cell maintenance and muscle regeneration
ResearchHuman
Researchers describe a metric for comparing amyloid structures
Provides a new metric for comparing amyloid and disease-associated protein structures, including TDP-43.
Research
A study compared three biomarkers in people with Alzheimer’s disease
Relevant to researchers comparing TDP-43, NfL, and GFAP across neurodegenerative diseases.
ResearchHumanCells
TMEM106B filament formation was linked more strongly to age than to TDP-43 or tau pathology
Offers human neuropathology data on age-dependent TMEM106B aggregation and its relationship with TDP-43 and tau.
ResearchHuman
HspB1 and HspB5 affect TDP-43 condensation and aggregation differently
Provides mechanistic data on chaperone regulation of TDP-43 condensation and aggregation
ResearchCommentaryHumanAnimal
A new research system models two key TDP-43 changes
Relevant to researchers studying TDP-43 mechanisms and experimental disease models
ResearchMouse
ALDOA inhibition slowed ALS progression in mice by reducing glycolysis-linked cell death
Directly informs research on glycolysis, inflammasome activation and motor-neuron pyroptosis in ALS models.
ResearchHumanMouse
Study links mislocalized TDP-43 to impaired glycolysis in ALS models
Provides mechanistic evidence linking TDP-43 pathology, HK1 mislocalization and glycolytic failure across models
ResearchReviewHumanAnimal
A review examines how TARDBP splicing may relate to ALS and FTD
Directly reviews TARDBP alternative splicing, isoforms and unresolved mechanisms in ALS and FTD.
ResearchHuman
A study found no clear difference in brain-volume loss between two TDP-43 conditions
Provides comparative MRI and autopsy data on TDP-43 pathology across neurodegenerative conditions.
ResearchHumanAnimal
TYK2 was linked to inflammation in TDP-43-related brain disease
Important for researchers studying TYK2, cryptic exons and TDP-43-associated neuroinflammation
ResearchHuman
FDG-PET model showed moderate accuracy for Alzheimer’s disease-related TDP-43 pathology
Provides a predictive FDG-PET model and candidate brain regions for TDP-43 research
ResearchHuman
A newly identified KIF5A variant disrupted exon 27 splicing in laboratory-grown motor neurons
Important for researchers studying KIF5A splicing, axonal transport and TDP-43 pathology.
ResearchHumanMouse
USP19 was linked to TDP-43 aggregation and ER stress in ALS-related models
Provides mechanistic and in vivo evidence linking USP19, TDP-43 aggregation, and ER stress
Research
Catching up with the 2024 Poster prize candidates
Mainly of interest to researchers following genetics, biomarkers, models and early-career research developments.
ResearchHuman
Autopsy study finds complex spinal protein pathology in people with chronic traumatic encephalopathy
Provides autopsy data on spinal tau, TDP-43, amyloid, and alpha-synuclein copathologies.
Research
Celebrating Early Career MND Researchers through the International Symposium on ALS/MND Poster Prize
Mainly of interest to researchers following MND progression datasets, MEG biomarkers, TBK1-TDP-43 biology and cell models.
ResearchHumanCells
KIAA1324 protein was reduced in neurons with TDP-43 pathology in ALS brains
Provides human tissue, iPSC-neuron and proteomic evidence about KIAA1324 downstream of TDP-43.
ResearchHuman
Ageing and mistranslation altered FUS and TDP-43 toxicity in yeast models
Provides mechanistic findings on FUS and TDP-43 aggregation, toxicity and ageing in yeast models
ResearchHuman
A study found reduced chaperone-mediated autophagy in spinal motor neurons affected by ALS
Directly informs research on chaperone-mediated autophagy, TDP-43 clearance and motor-neuron vulnerability.
ResearchHuman
A study found multiple protein abnormalities in many older brains
Provides pathology and biomarker data relevant to researchers studying overlapping neurodegenerative mechanisms.
ResearchHumanMouse
GSK3 inhibition reduced TDP-43 toxicity in neuron models
Important for researchers studying GSK3, caspase cleavage, TDP-43 proteostasis, and neuronal survival.
ResearchHumanAnimal
Researchers identify a cellular pathway that clears toxic TDP-43
Mainly of interest to researchers studying TDP-43 clearance, ubiquitination and endolysosomal mechanisms.
ResearchReviewHumanAnimal
A review examines how ubiquitin markings influence protein buildup in ALS
Summarises ubiquitin regulation of ALS-associated protein aggregation and degradation pathways
ResearchHumanMouse
TDP-43 mouse study links lasting behavioural problems to synaptic changes
Mainly of interest to researchers studying TDP-43, synaptic dysfunction, RNA mis-splicing and ALS-FTD mechanisms.
Trials & Treatments
Developing a new gene therapy
Relevant to researchers studying UNC13A, TDP-43 and antisense oligonucleotide development
Research
From blood and spinal fluid to skin – insights into different biomarkers for MND
Relevant to researchers studying microRNA, CSF calpain-2 and skin TDP-43 biomarkers.
Care & Living
Thinking and behaviour changes in MND
Relevant to clinicians assessing cognition, behaviour and possible survival implications
ResearchHumanAnimal
Human TDP-43 changes caused motor neuron disease-like features in zebrafish
Directly advances TDP-43 mechanism, disease modelling and preclinical drug-testing methods.
Trials & Treatments
Finding new treatments for MND
Mainly of interest to researchers following TDP-43, stem-cell, machine-learning and trial-design research.
ResearchHuman
Researchers find that TDP-43’s N-terminal domain affects RNA binding
Mainly of interest to researchers studying TDP-43 structure, RNA binding, and ALS mechanisms
ResearchHuman
A review examines links between TDP-43, immunity and the gut microbiome in ALS
Directly relevant to researchers studying TDP-43, neuroinflammation and the gut-brain axis.
Research
Researchers visualized TDP-43 aggregates inside neurons from ALS and FTLD tissue
Provides high-resolution evidence about TDP43 aggregation and early pathogenic events
Research
A study reports that TDP-43 loss of function triggers mitochondrial dysfunction and metabolic imbalance
Directly relevant to researchers studying TDP-43, mitochondrial dysfunction and ALS metabolism.
ResearchHuman
A study found no clear clinical associations for plasma TDP-43 in older adults
Relevant to researchers studying TDP-43 biomarkers and their association with dementia outcomes
Research
Symposium Highlights: Cells and MND
Relevant to researchers studying cell biology, TDP-43, iron biology and MND subtypes
ResearchCase reportHuman
A study linked genetic variants to age of onset in semantic-variant primary progressive aphasia
Provides comparative genotype and age-of-onset data linking svPPA with tau and TDP-43 pathways.
Research
Symposium Highlights: An Early Career Researcher’s Perspective
Mainly of interest to researchers following MND models, TDP-43 pathology and emerging diagnostic methods.
Research
How are proteins made and what happens when they go wrong in MND?
Summarises gene-to-protein processing and disease-linked SOD1 and TDP-43 mechanisms
Research
How can tissue donation help MND research?
Mainly of interest to researchers studying human tissue, neuropathology and MND mechanisms.
ResearchHumanMouse
A study links disrupted neuronal Wnt activity to TDP-43 changes in ALS
Provides mechanistic evidence linking GDE2, Wnt signaling, nucleocytoplasmic transport, and TDP-43 dysfunction.
ResearchHumanCells
TDP-43 was found to interact with DNA repair proteins in ALS samples and neuronal cells
Directly informs research on TDP43, mismatch repair and DNA-damage mechanisms in ALS neurons.
Research
Cutting-edge MND research at The Francis Crick Institute
Relevant to researchers studying iPSC models, glial interactions, RNA processing and gene therapy.
ResearchHumanMouse
VCP-activating compounds cleared TDP-43 aggregates in multisystem proteinopathy models
Mainly of interest to researchers studying VCP, nuclear proteostasis and TDP-43 aggregate clearance.
Research
TDP-43 was found to interact with two DNA repair proteins in ALS tissue and neuronal cells
Directly informs research on TDP-43 interactions, mismatch repair and neuronal DNA damage.
ResearchHuman
Digital holographic microscopy measured changes in nucleoli and TDP-43 cell assemblies
Provides a label-free imaging method for studying nucleoli, protein aggregation and TDP-43 condensates.
Research
A new way to detect faulty TDP-43 in MND
Relevant to researchers studying TDP-43 mechanisms and biomarker methods
Research
Shining a Spotlight on Early Career Researchers at the Symposium
Relevant to researchers studying FUS, TDP-43, synapses and motor-neuron disease models.
ResearchReviewHumanAnimal
A review links high MSG exposure to proposed mechanisms of neurodegeneration
Relevant to researchers examining excitotoxicity, disease mechanisms and blood-brain-barrier-penetrant phytochemicals.
Research
Symposium Preview: Meet the ALS/FTD Plenary Speakers…Part 2
Mainly of interest to researchers studying ALS-FTD mechanisms, biomarkers, models and genetic therapies.
Research
Symposium Preview: Meet the ALS/MND Plenary Speakers…Part 2
Mainly of interest to researchers following TDP-43, transcriptomics and clinical endpoints
Research
VCP-activating compounds improved TDP-43 aggregate clearance in laboratory cell models
Provides a cellular model and candidate VCP-activating compounds for studying nuclear proteostasis and aggregate clearance.
ResearchHuman
A brain-cell study found resistance to TDP-43 pathology in primary progressive aphasia
Offers mechanistic evidence about basal forebrain cholinergic neuron resistance to TDP-43 pathology.
ResearchHumanMouse
NOVA1 disruption was linked to early splicing changes in ALS motor neurons
Directly examines early NOVA1 dysfunction and alternative-splicing changes using human motor neurons and animal models.
ResearchHumanMouse
Slow motor neurons helped restore movement in a mouse model of ALS
Directly informs TDP-43 pathology, motor-neuron subtype vulnerability, and compensatory reinnervation mechanisms.
ResearchHuman
Huntingtin expansions were found in a small number of patients with FTD or ALS syndromes
Mainly of interest to researchers studying repeat expansions, ALS genetics and TDP-43 pathology