ResearchHuman
A CSF protein study identified genetic signatures linked to frontotemporal lobar degeneration
Directly informs proteomic signatures, genetic subgroup biology and diagnostic panel development.
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ResearchHuman
Study classifies 12 TARDBP variants as likely pathogenic in ALS
Mainly of interest to researchers studying TARDBP mechanisms, variant classification and cellular models.
ResearchHuman
A liver cancer study links higher TARDBP expression with poorer outcomes and weaker immune responses
Offers context on TARDBP/TDP-43 function and immune biology outside MND.
ResearchReviewHumanAnimal
A review examines how TARDBP splicing may relate to ALS and FTD
Directly reviews TARDBP alternative splicing, isoforms and unresolved mechanisms in ALS and FTD.
Research Compass
Stem-cell vesicles improved ALS motor neurons in laboratory models
Covers current findings across biomarkers, mechanisms, trials, genetics and translational research
ResearchCase reportHuman
A study linked genetic variants to age of onset in semantic-variant primary progressive aphasia
Provides comparative genotype and age-of-onset data linking svPPA with tau and TDP-43 pathways.
ResearchHuman
A Chinese study found rare genetic variants in sporadic Alzheimer’s disease and frontotemporal lobar degeneration
Mainly of interest to researchers studying genetic overlap and variants across neurodegenerative diseases.