Research Reporting
NfL changes may help predict treatment benefit in ALS
Mainly of interest to researchers studying ALS biomarkers and therapeutic response
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ResearchHuman
Tofersen treatment did not lower blood SOD1 activity in a study of people with SOD1-related ALS
Mainly of interest to researchers studying SOD1 activity, mutation effects and tofersen mechanisms.
ResearchHumanMouse
An anti-TDP-43 intrabody changed disease-related pathways but did not improve symptoms in ALS mice
Directly informs TDP-43 mechanisms, neuroinflammation, metabolism and biomarker target engagement
ResearchHuman
A study maps the order of biomarker and clinical changes across frontotemporal degeneration syndromes
Provides longitudinal biomarker timing and a framework for staging FTLD-associated syndromes.
ResearchReviewHumanAnimal
A review outlines approaches to targeting TDP-43 in sporadic ALS
Mainly of interest to researchers studying TDP-43 pathology, cryptic exons, biomarkers and trial methodology.
Trials & TreatmentsHuman
A French real-world study links tofersen with slower decline in SOD1-ALS
Relevant to clinicians evaluating real-world tofersen effectiveness, biomarkers, survival and study limitations.
Research Reporting
Longer NFL careers tied to higher ALS and neurodegenerative death rates
Mainly of interest to researchers studying environmental exposure, neurodegeneration and ALS mortality.
ResearchHuman
Troponin T and neurofilament light chain captured different aspects of ALS progression
Mainly of interest to researchers studying complementary ALS biomarkers and disease modelling.
ResearchSystematic reviewHuman
A review finds blood neurofilament light chain may help measure treatment effects in ALS trials
Relevant to researchers studying NfL validation and disease- or intervention-specific biomarker interpretation
ResearchReviewHuman
A review assesses neurofilament light chain as a biomarker in ALS and other neurological diseases
Relevant to researchers developing neuroaxonal injury biomarkers and multimodal validation strategies.
ResearchHuman
Former NFL players had higher rates of death from ALS and other neurodegenerative diseases
Important for researchers studying repetitive head impacts, ALS epidemiology, and competing-risk methods.
ResearchHuman
A study linked brain-fluid changes and neurofilament light to cognitive decline in familial frontotemporal lobar||||degค
Provides multimodal biomarker and mediation evidence across major FTLD genotypes
Community & Stories Reporting
Ex-NFL running back says he ‘chose to fight’ after his ALS diagnosis
Relevant to people seeking lived-experience perspectives after an ALS diagnosis
ResearchReview
A review outlines ALS mechanisms, biomarkers and possible treatment targets
Relevant to researchers comparing ALS mechanisms, biomarkers and treatment targets across neurodegenerative diseases
ResearchHuman
Gold Coast criteria were more sensitive for ALS diagnosis than older criteria in a specialist centre
Relevant to clinicians applying Gold Coast criteria and interpreting neurofilaments in diagnosis.
ResearchHuman
A study found plasma p-tau181 was elevated in people with ALS but did not track cognition or disease progression
Important for researchers studying p-tau181, NfL and ALS disease mechanisms
Research
A study compared three biomarkers in people with Alzheimer’s disease
Relevant to researchers comparing TDP-43, NfL, and GFAP across neurodegenerative diseases.
ResearchHuman
UK Biobank analysis finds more pathogenic SOD1 carriers than expected from clinical reports
Mainly of interest to researchers studying SOD1 penetrance, prevalence and biomarkers.
Trials & TreatmentsHumanAnimal
A screen of ALS patient-derived motor neurons identified compounds that raise neurofilament light chain levels
Mainly of interest to researchers studying iPSC disease models, neurofilament biology and high-throughput screening
ResearchReviewHuman
A multidisciplinary paper sets out a roadmap for using neurofilament light testing in clinical practice
Mainly of interest to researchers developing and validating neurofilament biomarkers and clinical translation methods.
ResearchHuman
CSF protein patterns and CXCL7 were linked to ALS progression and survival
Mainly of interest to researchers studying proteomic signatures, ALS heterogeneity, and CXCL7 biology.
ResearchHuman
Brain network changes were detected across clinical stages in C9orf72 carriers
Important for researchers studying stage-specific neuroimaging biomarkers and disease trajectories.
Trials & Treatments
How can biomarkers be used in clinical trials in MND?
Mainly of interest to researchers studying biomarkers and trial outcome measures.
Research
What biomarkers do we have for MND?
Mainly of interest to researchers tracking neurofilament and emerging MND biomarker work.
Trials & Treatments
MIROCALS: breaking down the trial results
Relevant to clinicians interpreting MIROCALS efficacy, subgroup findings and safety signals.
Research
Pre-symptomatic detection and early diagnosis in MND
Mainly of interest to researchers studying presymptomatic disease and prevention trial design