ResearchHuman
A FUS gene variant was linked to tremor and movement symptoms in a young adult with motor neuron disease
Mainly of interest to researchers studying FUS variants and phenotypic heterogeneity.
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ResearchHuman
A review found no new ALS-causing variants in four unresolved genomic regions
Relevant to researchers studying ALS gene discovery, pedigrees and rare-variant methods.
ResearchHuman
A Chinese study describes clinical and genetic differences in young-onset ALS
Mainly of interest to researchers studying age-dependent ALS genetics and trial design.
ResearchReviewHuman
Brazilian experts recommend early genetic testing for people with ALS
Relevant to clinicians updating ALS genetic-testing practice and counselling
ResearchHuman
A Lithuanian study found pathogenic genetic variants in 15.7% of patients with motor neuron disease
Mainly of interest to researchers studying MND genetics and regional variation
ResearchReviewHumanAnimal
A review links R-loop regulation to several neurological diseases including ALS
Mainly of interest to researchers studying R-loops, TDP-43/FUS, SETX and neurodegeneration
ResearchHuman
A case report links focal epilepsy with FUS-associated ALS
Mainly of interest to researchers studying FUS-ALS phenotypes and genotype-phenotype links.
ResearchHumanMouse
A perspective calls for broader ALS models beyond protein-focused mouse studies
Relevant to researchers studying protein pathology, transgenic models, and translational ALS methods.
ResearchHumanAnimal
A zebrafish ALS model identified tribenzylamine as a candidate compound
Offers a FUS zebrafish screening platform and mechanistic evidence for tribenzylamine.
ResearchReviewHumanAnimal
A review examines how phase separation may contribute to ALS-related protein aggregation
Provides a broad review of phase separation, protein aggregation and candidate therapeutic strategies involving TDP-43 and FUS.
ResearchHumanAnimal
FUS toxicity in fruit flies was linked to RNA polymerase II
Important for researchers studying FUS toxicity, RNA polymerase II interactions and disease models.
Research Compass
Stem-cell vesicles improved ALS motor neurons in laboratory models
Covers current findings across biomarkers, mechanisms, trials, genetics and translational research
ResearchHuman
Ageing and mistranslation altered FUS and TDP-43 toxicity in yeast models
Provides mechanistic findings on FUS and TDP-43 aggregation, toxicity and ageing in yeast models
ResearchHumanAnimal
FUS-ALS motor neuron compartments show distinct molecular changes linked to axon damage
Provides compartment-specific transcriptomic data and identifies PLK1, extracellular-matrix and axonal pathways for further study.
Research
How the H1.2-FUS complex may contribute to ALS
Important for researchers studying FUS biology, nuclear transport and ALS pathogenesis
ResearchHuman
ALS-associated proteins were found to regulate UNC13A through REST
Provides mechanistic evidence linking multiple ALS-associated RNA-binding proteins, REST and UNC13A in motor neurons.
Research
Cutting-edge MND research at The Francis Crick Institute
Relevant to researchers studying iPSC models, glial interactions, RNA processing and gene therapy.
Research
Shining a Spotlight on Early Career Researchers at the Symposium
Relevant to researchers studying FUS, TDP-43, synapses and motor-neuron disease models.
Advocacy
Reuniting the MND community at the 34th International Symposium on ALS/MND
Mainly of interest to researchers following new mechanisms, biomarkers, trials and collaborations.
Research
Age at onset predicts disease course in FUS-associated ALS
Mainly of interest to researchers studying FUS genotype-phenotype correlations and therapeutic windows.